CovidSeniorV1, Main, Exploration, bibRecord, 000382

Outcomes and implications of diarrhea in patients with SARS-CoV-2 infection.

Identifieur interne : 000382 ( Main/Exploration ); précédent : 000381; suivant : 000383

Outcomes and implications of diarrhea in patients with SARS-CoV-2 infection.

Auteurs : Haitao Shang [République populaire de Chine] ; Tao Bai [République populaire de Chine] ; Yuhua Chen [République populaire de Chine] ; Chao Huang [République populaire de Chine] ; Shengyan Zhang [République populaire de Chine] ; Pengcheng Yang [République populaire de Chine] ; Lei Zhang [République populaire de Chine] ; Xiaohua Hou [République populaire de Chine]

Source :

Scandinavian journal of gastroenterology [ 1502-7708 ] ; 2020.

RBID : pubmed:32749177

Descripteurs français

KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Analyse de survie (MeSH), Appréciation des risques (MeSH), Chine (épidémiologie), Comorbidité (MeSH), Diarrhée (physiopathologie), Diarrhée (virologie), Diarrhée (épidémiologie), Femelle (MeSH), Hospitalisation (statistiques et données numériques), Humains (MeSH), Incidence (MeSH), Infections à coronavirus (épidémiologie), Maladies transmissibles émergentes (épidémiologie), Mortalité hospitalière (tendances), Mâle (MeSH), Pandémies (MeSH), Pneumopathie virale (épidémiologie), Statistique non paramétrique (MeSH), Sujet âgé (MeSH), Épidémies de maladies (statistiques et données numériques), Études de cohortes (MeSH), Études rétrospectives (MeSH).
MESH :
- physiopathologie : Diarrhée.
- statistiques et données numériques : Hospitalisation, Épidémies de maladies.
- tendances : Mortalité hospitalière.
- virologie : Diarrhée.
- épidémiologie : Chine, Diarrhée, Infections à coronavirus, Maladies transmissibles émergentes, Pneumopathie virale.
- Adulte, Adulte d'âge moyen, Analyse de survie, Appréciation des risques, Comorbidité, Femelle, Humains, Incidence, Mâle, Pandémies, Statistique non paramétrique, Sujet âgé, Études de cohortes, Études rétrospectives.
Wicri :
- geographic : République populaire de Chine.

English descriptors

KwdEn :
- Adult (MeSH), Aged (MeSH), China (epidemiology), Cohort Studies (MeSH), Communicable Diseases, Emerging (epidemiology), Comorbidity (MeSH), Coronavirus Infections (epidemiology), Diarrhea (epidemiology), Diarrhea (physiopathology), Diarrhea (virology), Disease Outbreaks (statistics & numerical data), Female (MeSH), Hospital Mortality (trends), Hospitalization (statistics & numerical data), Humans (MeSH), Incidence (MeSH), Male (MeSH), Middle Aged (MeSH), Pandemics (MeSH), Pneumonia, Viral (epidemiology), Retrospective Studies (MeSH), Risk Assessment (MeSH), Statistics, Nonparametric (MeSH), Survival Analysis (MeSH).
MESH :
- geographic , epidemiology : China.
- epidemiology : Communicable Diseases, Emerging, Coronavirus Infections, Diarrhea, Pneumonia, Viral.
- physiopathology : Diarrhea.
- statistics & numerical data : Disease Outbreaks, Hospitalization.
- trends : Hospital Mortality.
- virology : Diarrhea.
- Adult, Aged, Cohort Studies, Comorbidity, Female, Humans, Incidence, Male, Middle Aged, Pandemics, Retrospective Studies, Risk Assessment, Statistics, Nonparametric, Survival Analysis.

Abstract

BACKGROUND AND AIMS

Diarrhea was not uncommon in patients with coronavirus disease 2019 (COVID-19), but the significance remains undetermined.

METHODS

This retrospective study included 157 diarrhea cases form 564 hospitalized COVID-19 patients who were admitted to Wuhan Union Hospital from January 20 to February 29, 2020. Clinical characteristics, the course and the outcome of patients with diarrhea were analyzed. The correlation between diarrhea and fecal presence of coronavirus was also determined.

RESULTS

The overall morbidity of diarrhea was 27.8% (157/564) in COVID-19 patients. Among them, 38 cases presented only with diarrhea, and 119 cases in both diarrhea and respiratory symptoms. Patients with diarrhea and respiratory symptoms had higher levels of inflammatory activity, longer hospital stay (27.5 vs. 23.0 vs. 22.0 days,

CONCLUSIONS

Diarrhea caused by high enteric viral burden may lead to long course and poor outcome in COVID-19 patients. The patients with diarrhea and respiratory symptoms were prone to serious condition, and had worse outcomes. However, the patients with diarrhea alone showed mild illness but delayed health-seeking.

DOI: 10.1080/00365521.2020.1800078
PubMed: 32749177

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000847
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Le document en format XML

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<term>Cohort Studies (MeSH)</term>
<term>Communicable Diseases, Emerging (epidemiology)</term>
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<term>Diarrhea (virology)</term>
<term>Disease Outbreaks (statistics & numerical data)</term>
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<term>Hospital Mortality (trends)</term>
<term>Hospitalization (statistics & numerical data)</term>
<term>Humans (MeSH)</term>
<term>Incidence (MeSH)</term>
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<term>Middle Aged (MeSH)</term>
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<term>Pneumonia, Viral (epidemiology)</term>
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<term>Diarrhée (physiopathologie)</term>
<term>Diarrhée (virologie)</term>
<term>Diarrhée (épidémiologie)</term>
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<term>Hospitalisation (statistiques et données numériques)</term>
<term>Humains (MeSH)</term>
<term>Incidence (MeSH)</term>
<term>Infections à coronavirus (épidémiologie)</term>
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<term>Pneumopathie virale (épidémiologie)</term>
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<term>Sujet âgé (MeSH)</term>
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<term>Études de cohortes (MeSH)</term>
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<term>Diarrhea</term>
<term>Pneumonia, Viral</term>
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<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Diarrhea</term>
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<term>Pneumopathie virale</term>
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<term>Aged</term>
<term>Cohort Studies</term>
<term>Comorbidity</term>
<term>Female</term>
<term>Humans</term>
<term>Incidence</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Pandemics</term>
<term>Retrospective Studies</term>
<term>Risk Assessment</term>
<term>Statistics, Nonparametric</term>
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<term>Adulte d'âge moyen</term>
<term>Analyse de survie</term>
<term>Appréciation des risques</term>
<term>Comorbidité</term>
<term>Femelle</term>
<term>Humains</term>
<term>Incidence</term>
<term>Mâle</term>
<term>Pandémies</term>
<term>Statistique non paramétrique</term>
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<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND AND AIMS</b>
</p>
<p>Diarrhea was not uncommon in patients with coronavirus disease 2019 (COVID-19), but the significance remains undetermined.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>This retrospective study included 157 diarrhea cases form 564 hospitalized COVID-19 patients who were admitted to Wuhan Union Hospital from January 20 to February 29, 2020. Clinical characteristics, the course and the outcome of patients with diarrhea were analyzed. The correlation between diarrhea and fecal presence of coronavirus was also determined.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>The overall morbidity of diarrhea was 27.8% (157/564) in COVID-19 patients. Among them, 38 cases presented only with diarrhea, and 119 cases in both diarrhea and respiratory symptoms. Patients with diarrhea and respiratory symptoms had higher levels of inflammatory activity, longer hospital stay (27.5 vs. 23.0 vs. 22.0 days, </p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>Diarrhea caused by high enteric viral burden may lead to long course and poor outcome in COVID-19 patients. The patients with diarrhea and respiratory symptoms were prone to serious condition, and had worse outcomes. However, the patients with diarrhea alone showed mild illness but delayed health-seeking.</p>
</div>
</front>
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<DateCompleted><Year>2020</Year>
<Month>09</Month>
<Day>22</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>09</Month>
<Day>22</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1502-7708</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>55</Volume>
<Issue>9</Issue>
<PubDate><Year>2020</Year>
<Month>09</Month>
</PubDate>
</JournalIssue>
<Title>Scandinavian journal of gastroenterology</Title>
<ISOAbbreviation>Scand J Gastroenterol</ISOAbbreviation>
</Journal>
<ArticleTitle>Outcomes and implications of diarrhea in patients with SARS-CoV-2 infection.</ArticleTitle>
<Pagination><MedlinePgn>1049-1056</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1080/00365521.2020.1800078</ELocationID>
<Abstract><AbstractText Label="BACKGROUND AND AIMS">Diarrhea was not uncommon in patients with coronavirus disease 2019 (COVID-19), but the significance remains undetermined.</AbstractText>
<AbstractText Label="METHODS">This retrospective study included 157 diarrhea cases form 564 hospitalized COVID-19 patients who were admitted to Wuhan Union Hospital from January 20 to February 29, 2020. Clinical characteristics, the course and the outcome of patients with diarrhea were analyzed. The correlation between diarrhea and fecal presence of coronavirus was also determined.</AbstractText>
<AbstractText Label="RESULTS">The overall morbidity of diarrhea was 27.8% (157/564) in COVID-19 patients. Among them, 38 cases presented only with diarrhea, and 119 cases in both diarrhea and respiratory symptoms. Patients with diarrhea and respiratory symptoms had higher levels of inflammatory activity, longer hospital stay (27.5 vs. 23.0 vs. 22.0 days, <i>p</i>
 = .029) and higher odds ratio of mortality (3.2 times and 2.2 times, respectively) than those with diarrhea only or respiratory symptoms only. However, patients with diarrhea had longer time from onset to admission (14.5 days vs. 11.0 days, <i>p</i>
 = .04), higher positive viral RNA in stool (80.0% vs. 52.4%, <i>p</i>
 = .016) than those with both diarrhea and respiratory symptoms.</AbstractText>
<AbstractText Label="CONCLUSIONS">Diarrhea caused by high enteric viral burden may lead to long course and poor outcome in COVID-19 patients. The patients with diarrhea and respiratory symptoms were prone to serious condition, and had worse outcomes. However, the patients with diarrhea alone showed mild illness but delayed health-seeking.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Shang</LastName>
<ForeName>Haitao</ForeName>
<Initials>H</Initials>
<Identifier Source="ORCID">0000-0002-6810-3263</Identifier>
<AffiliationInfo><Affiliation>Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bai</LastName>
<ForeName>Tao</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Yuhua</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Huang</LastName>
<ForeName>Chao</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Shengyan</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yang</LastName>
<ForeName>Pengcheng</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Lei</ForeName>
<Initials>L</Initials>
<Identifier Source="ORCID">0000-0003-4921-8986</Identifier>
<AffiliationInfo><Affiliation>Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hou</LastName>
<ForeName>Xiaohua</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType>
<PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>08</Month>
<Day>04</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Scand J Gastroenterol</MedlineTA>
<NlmUniqueID>0060105</NlmUniqueID>
<ISSNLinking>0036-5521</ISSNLinking>
</MedlineJournalInfo>
<SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName>
</SupplMeshList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002681" MajorTopicYN="N" Type="Geographic">China</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D021821" MajorTopicYN="N">Communicable Diseases, Emerging</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015897" MajorTopicYN="N">Comorbidity</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003967" MajorTopicYN="N">Diarrhea</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004196" MajorTopicYN="N">Disease Outbreaks</DescriptorName>
<QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017052" MajorTopicYN="N">Hospital Mortality</DescriptorName>
<QualifierName UI="Q000639" MajorTopicYN="Y">trends</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006760" MajorTopicYN="N">Hospitalization</DescriptorName>
<QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015994" MajorTopicYN="N">Incidence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018570" MajorTopicYN="N">Risk Assessment</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018709" MajorTopicYN="N">Statistics, Nonparametric</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016019" MajorTopicYN="N">Survival Analysis</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Coronavirus disease 2019</Keyword>
<Keyword MajorTopicYN="Y">diarrhea</Keyword>
<Keyword MajorTopicYN="Y">digestive system</Keyword>
<Keyword MajorTopicYN="Y">fecal–oral transmission</Keyword>
<Keyword MajorTopicYN="Y">severe acute respiratory syndrome coronavirus 2</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>8</Month>
<Day>5</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>9</Month>
<Day>23</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>8</Month>
<Day>5</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">32749177</ArticleId>
<ArticleId IdType="doi">10.1080/00365521.2020.1800078</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
<region><li>Hubei</li>
</region>
<settlement><li>Wuhan</li>
</settlement>
</list>
<tree><country name="République populaire de Chine"><region name="Hubei"><name sortKey="Shang, Haitao" sort="Shang, Haitao" uniqKey="Shang H" first="Haitao" last="Shang">Haitao Shang</name>
</region>
<name sortKey="Bai, Tao" sort="Bai, Tao" uniqKey="Bai T" first="Tao" last="Bai">Tao Bai</name>
<name sortKey="Chen, Yuhua" sort="Chen, Yuhua" uniqKey="Chen Y" first="Yuhua" last="Chen">Yuhua Chen</name>
<name sortKey="Hou, Xiaohua" sort="Hou, Xiaohua" uniqKey="Hou X" first="Xiaohua" last="Hou">Xiaohua Hou</name>
<name sortKey="Huang, Chao" sort="Huang, Chao" uniqKey="Huang C" first="Chao" last="Huang">Chao Huang</name>
<name sortKey="Yang, Pengcheng" sort="Yang, Pengcheng" uniqKey="Yang P" first="Pengcheng" last="Yang">Pengcheng Yang</name>
<name sortKey="Zhang, Lei" sort="Zhang, Lei" uniqKey="Zhang L" first="Lei" last="Zhang">Lei Zhang</name>
<name sortKey="Zhang, Shengyan" sort="Zhang, Shengyan" uniqKey="Zhang S" first="Shengyan" last="Zhang">Shengyan Zhang</name>
</country>
</tree>
</affiliations>
</record>

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	Serveur d'exploration sur la COVID chez les séniors
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Outcomes and implications of diarrhea in patients with SARS-CoV-2 infection.

Outcomes and implications of diarrhea in patients with SARS-CoV-2 infection.

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